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KMID : 1161520050090020095
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Animal Cells and Systems
2005 Volume.9 No. 2 p.95 ~ p.100
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Human G-protein β3 subunit C825T polymorphism is associated with serum total cholesterol and LDL-cholesterol levels in Koreans
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Kang Byung-Yong
Kang Chin-Yang
Lee Kang-Oh
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Abstract
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Essential hypertension results from the complex interaction between genetic and environmental factors. A C825T polymorphism of the gene encoding G?protein β3 subunit (GNB3), associated with enhanced G?protein coupled signaling and increased Na+?H+ exchanger, has been implicated in the development of essential hypertension in several human populations, especially in Caucasian population. We examined the disease relevance of this candidate gene by performing an association study in a study group of Korean heritage. Participants comprised 109 essential hypertensives and 109 normotensives, respectively. Genotyping was performed with PCR?βsaJI restriction digestion method. Observed genotype frequencies were in Hardy?Weinberg equilibrium in all groups. Genotype and allele frequencies did not differ significantly between normotensives and essential hypertensives (P>0.05). However, the serum total cholesterol (TC) and LDL?cholesterol levels were significantly higher in subjects with the TT genotype compared to those with the CC or CT genotypes in normotensives of our study subjects (P<0.05). Thus, these results suggest that GNB3/C825T polymorphism might be significantly associated with abnormality in serum lipid metabolism.
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KEYWORD
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essential hypertension, G-protein β3 subunit, Korean population
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